Plague
B
B-Tier — Good, Situationally Strong
Rune Recipe
Cham 
Shael 
Um
Insert in order: Cham → Shael → Um
Get These Runes
Need runes for this runeword? Find them on Traderie — D2R's most active trading marketplace.
Stats & Properties
+220-320% Enhanced Damage
20% Chance To Cast Level 12 Lower Resist When Struck
25% Chance To Cast Level 15 Poison Nova On Striking
-23% To Enemy Poison Resistance
+(0.375 Per Character Level) 0.375-37.125% Deadly Strike (Based on Character Level)
Level 13-17 Cleansing Aura When Equipped
+1-2 To All Skills
+20% Increased Attack Speed
+25% Chance of Open Wounds
Freezes Target +3
--- Rune Bonuses ---
Cham: 32% Chance Freeze Target 3 sec
Shael: +20 IAS
Um: 25% Chance of Open Wounds
How to Socket Your Base
⚔️ Weapon
Ral + Amn + Perfect Amethyst + Normal Weapon
Adds 1-6 sockets (random). Cannot exceed item's max sockets.
Larzuk Quest Reward — Gives max sockets on normal items. Best way to guarantee exactly 3 sockets on the right base.
Best Base Items for Plague
Indestructible + fastest attack speed. Plague Phase Blade maximizes Poison Nova proc frequency.
Budget: Crystal Sword — Budget 4-socket option. Works for the Cleansing aura utility.
Where it drops Hell for Phase Blade.
Socket ilvl Phase Blade: max 6 sockets. Larzuk gives 6. For 5os: find a natural drop or cube recipe. Crystal Sword: ilvl ≤25 for 4 sockets.
How to socket Phase Blade: Larzuk gives 6os. For 5os runewords, find a 5os drop or cube recipe. Crystal Sword: Larzuk on Normal Cows drop.
Best farming spots Hell Mephisto (Phase Blade) · Normal Cows (Crystal Sword)
Terror Zones scale monster levels to your character level (up to 99), so any terrorized area can drop elite bases — great supplemental farming.
Find more runewords you can build
Enter your rune stash in the calculator to see everything you can make right now.
⚔️ Get More Loot with Better Gear
Upgrade your D2R setup. Buying through these links supports DiabloBytes at no extra cost to you.
Mouse Pads
SteelSeries QcK XXL Desk Mat
Massive 36"×16" desk mat. Smooth tracking for those clutch Enigma teleports.
~$35View on Amazon ↗
Best ValueGaming Mice
Razer Basilisk V3
11 programmable buttons with HyperScroll. Wired reliability at an incredible price.
~$40View on Amazon ↗
Editor's ChoiceGaming PCs
CyberPowerPC Gamer Xtreme VR
i7-13700F + RTX 4060 Ti 16GB + DDR5. 820 Amazon reviews, 4.6 stars.
~$1,299View on Amazon ↗
As an Amazon Associate, DiabloBytes earns from qualifying purchases.